Ammonium → Tert-butyl 4-(2-fluoro-3-formylbenzoyl)piperazine-1-carboxylate

HRID 302018Notes

Reaction equation

HRID 302018 reaction equation
[Br:1][c:2]1[c:3]([F:23])[c:4]([C:5](=[O:6])[N:7]2[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2)[cH:20][cH:21][cH:22]1.[CH2:25]([Mg+:26])[CH:27]([CH3:28])[CH3:29].[CH3:30][N:31]([CH:32]=[O:33])[CH3:34].[Cl-:24].[Cl-:35].[NH4+:36].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[c:2]1([CH:32]=[O:33])[c:3]([F:23])[c:4]([C:5](=[O:6])[N:7]2[CH2:8][CH2:9][N:10]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:11][CH2:12]2)[cH:20][cH:21][cH:22]1

Participants

7

Reactant 6

HCID 223AmmoniumHCID 312Chloride2×HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 57562603Tert-butyl 4-(3-bromo-2-fluorobenzoyl)piperazine-1-carboxylateHCID 178448189HCID 178448189, compound

Product 1

HCID 57562639Tert-butyl 4-(2-fluoro-3-formylbenzoyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-6b86022c68a94e3e8f6896166ed3f9a0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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