Dimethylformamide → 2-chloro-N-[3-[4-[4-(2-methoxyethoxy)-N-[(4-methyl-3-pyridinyl)methyl]anilino]piperidin-1-yl]butyl]-4-methylpyridine-3-carboxamide

HRID 302423Notes

Reaction equation

HRID 302423 reaction equation
[CH3:32][CH2:33][N:34]=[C:35]=[N:36][CH2:37][CH2:38][CH2:39][N:40]([CH3:41])[CH3:42].[CH:64]([N:65]([CH2:66][CH3:67])[CH:68]([CH3:69])[CH3:70])([CH3:71])[CH3:72].[Cl:53][c:54]1[c:55]([C:56](=[O:57])[OH:58])[c:59]([CH3:63])[cH:60][cH:61][n:62]1.[NH2:1][CH2:2][CH2:3][CH:4]([CH3:5])[N:6]1[CH2:7][CH2:8][CH:9]([N:12]([CH2:13][c:14]2[cH:15][n:16][cH:17][cH:18][c:19]2[CH3:20])[c:21]2[cH:22][cH:23][c:24]([O:27][CH2:28][CH2:29][O:30][CH3:31])[cH:25][cH:26]2)[CH2:10][CH2:11]1.[O:73]=[CH:74][N:75]([CH3:76])[CH3:77].[OH:43][n:44]1[c:45]2[c:46]([cH:47][cH:48][cH:49][cH:50]2)[n:51][n:52]1>>[NH:1]([CH2:2][CH2:3][CH:4]([CH3:5])[N:6]1[CH2:7][CH2:8][CH:9]([N:12]([CH2:13][c:14]2[cH:15][n:16][cH:17][cH:18][c:19]2[CH3:20])[c:21]2[cH:22][cH:23][c:24]([O:27][CH2:28][CH2:29][O:30][CH3:31])[cH:25][cH:26]2)[CH2:10][CH2:11]1)[C:56]([c:55]1[c:54]([Cl:53])[n:62][cH:61][cH:60][c:59]1[CH3:63])=[O:57]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 154837662-Chloro-4-methylpyridine-3-carboxylic acidHCID 689697291-(4-aminobutan-2-yl)-N-[4-(2-methoxyethoxy)phenyl]-N-[(4-methyl-3-pyridinyl)methyl]piperidin-4-amine

Product 1

HCID 750377662-chloro-N-[3-[4-[4-(2-methoxyethoxy)-N-[(4-methyl-3-pyridinyl)methyl]anilino]piperidin-1-yl]butyl]-4-methylpyridine-3-carboxamide

Sources & evidence

ORD record
ord-fc0a8fe3bbcb45839c3de3852a349992
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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