反应详情

A mixture of pentynol (8.0 g, 95 mmol), t-butyldiphenylsilylchloride (28 g, 114 mmol) and Et3N (14 g, 138 mmol) in CH2Cl2 is stirred at room temperature for 16 h, treated with 1M K2CO3 and extracted with CH2Cl2. The combined extracts are dried over MgSO4 and concentrated in vacuo. The residue is purified by filtration on a silica pad to obtain 30 g of t-butylpent-4-ynyloxy diphenyl silane (yield: 98%

1. extractionextracted with CH2Cl2
2. dry with materialThe combined extracts are dried over MgSO4
3. concentrationconcentrated in vacuo
4. filtrationThe residue is purified by filtration on a silica pad