Tetrahydrofuran → N-({1-[4-(5-Ethynyl-2-oxo-2H-pyridin-1yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

HRID 307241Notes

Reaction equation

HRID 307241 reaction equation
[C:36](#[CH:37])[Si:38]([CH3:39])([CH3:40])[CH3:41].[CH2:43]([N+:44]([CH2:45][CH2:46][CH2:47][CH3:48])([CH2:49][CH2:50][CH2:51][CH3:52])[CH2:53][CH2:54][CH2:55][CH3:56])[CH2:57][CH2:58][CH3:59].[CH2:60]1[O:61][CH2:62][CH2:63][CH2:64]1.[Cu:65][I:66].[F-:42].[I:1][c:2]1[cH:3][cH:4][c:5](=[O:35])[n:6]([CH:8]2[CH2:9][CH2:10][CH:11]([N:14]3[CH2:15][CH:16]([NH:18][C:19](=[O:20])[CH2:21][NH:22][C:23]([c:24]4[cH:25][c:26]([C:30]([F:31])([F:32])[F:33])[cH:27][cH:28][cH:29]4)=[O:34])[CH2:17]3)[CH2:12][CH2:13]2)[cH:7]1>>[c:2]1([C:36]#[CH:37])[cH:3][cH:4][c:5](=[O:35])[n:6]([CH:8]2[CH2:9][CH2:10][CH:11]([N:14]3[CH2:15][CH:16]([NH:18][C:19](=[O:20])[CH2:21][NH:22][C:23]([c:24]4[cH:25][c:26]([C:30]([F:31])([F:32])[F:33])[cH:27][cH:28][cH:29]4)=[O:34])[CH2:17]3)[CH2:12][CH2:13]2)[cH:7]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 28179Fluoride IonHCID 66111TrimethylsilylacetyleneHCID 49764697N-({1-[4-(5-Iodo-2-oxo-2H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Product 1

HCID 49764698N-({1-[4-(5-Ethynyl-2-oxo-2H-pyridin-1yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Sources & evidence

ORD record
ord-36481010b58c4a23a6ad7c6e74ce4c1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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