反应详情

To ethylpiperidine-4-carboxylate (1 eq) in ethanol was added 2-bromo-1-methoxyethane (1 eq) and potassium carbonate 2 eq) and the resulting mixture was refluxed for 16 h. The mixture was then filtered and concentrated. To it was then added ethanol and water (3:1) and sodium hydroxide (1 eq) and it was refluxed for 16 h. The resulting 1-(2-methoxyethyl)piperidine-4-carboxylic acid was then azeotroped with toluene. MS: MH+=188.

1. temperaturewas refluxed for 16 h
2. filtrationThe mixture was then filtered
3. concentrationconcentrated
4. customThe resulting 1-(2-methoxyethyl)piperidine-4-carboxylic acid was then azeotroped with toluene