Dichloromethane → 6-Hydroxy-3-(3-methoxy-4-((1-pyrrolidinyl)methyl)benzyl)-2-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)benzo(b)thiophene

HRID 307892Notes

Reaction equation

HRID 307892 reaction equation
[Al+3:42].[CH2:47]([SiH:48]([CH2:49][CH3:50])[CH2:51][CH3:52])[CH3:53].[CH2:54]1[O:55][CH2:56][CH2:57][CH2:58]1.[CH3:1][O:2][c:3]1[cH:4][c:5]([C:15](=[O:16])[c:17]2[c:18]3[c:19]([s:20][c:21]2-[c:22]2[cH:23][cH:24][c:25]([O:28][CH2:29][CH2:30][N:31]4[CH2:32][CH2:33][CH2:34][CH2:35]4)[cH:26][cH:27]2)[cH:36][c:37]([OH:40])[cH:38][cH:39]3)[cH:6][cH:7][c:8]1[CH2:9][N:10]1[CH2:11][CH2:12][CH2:13][CH2:14]1.[Cl:59][CH2:60][Cl:61].[H-:41].[H-:44].[H-:45].[H-:46].[Li+:43]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:15][c:17]2[c:18]3[c:19]([s:20][c:21]2-[c:22]2[cH:23][cH:24][c:25]([O:28][CH2:29][CH2:30][N:31]4[CH2:32][CH2:33][CH2:34][CH2:35]4)[cH:26][cH:27]2)[cH:36][c:37]([OH:40])[cH:38][cH:39]3)[cH:6][cH:7][c:8]1[CH2:9][N:10]1[CH2:11][CH2:12][CH2:13][CH2:14]1

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 12052TriethylsilaneHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 10650441HCID 10650441, compound

Product 1

HCID 104824786-Hydroxy-3-(3-methoxy-4-((1-pyrrolidinyl)methyl)benzyl)-2-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)benzo(b)thiophene

Sources & evidence

ORD record
ord-5004228f5a364b82978bf52fce3d20e1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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