Benzene → Ethyl 4-cyclopropyl-4-oxobutanoate

HRID 308895Notes

Reaction equation

HRID 308895 reaction equation
[CH3:21][CH2:22][O:23][C:24](=[O:25])[CH3:26].[CH:9]1([C:12](=[O:13])[Cl:14])[CH2:10][CH2:11]1.[Cu:27].[I:1][CH2:2][CH2:3][C:4](=[O:5])[O:6][CH2:7][CH3:8].[Pd:29]([Cl:30])[Cl:31].[Zn:28].[c:32]1([P:33]([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[cH:46][cH:47][cH:48][cH:49][cH:50]1.[c:51]1([P:52]([c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[cH:65][cH:66][cH:67][cH:68][cH:69]1.[cH:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1>>[CH2:2]([CH2:3][C:4](=[O:5])[O:6][CH2:7][CH3:8])[C:12]([CH:9]1[CH2:10][CH2:11]1)=[O:13]

Participants

9

Reactant 8

HCID 241BenzeneHCID 8857Ethyl AcetateHCID 11776Triphenylphosphine2×HCID 23978CopperHCID 23994ZincHCID 24290Palladium ChlorideHCID 77637Cyclopropanecarbonyl chlorideHCID 10911297Ethyl 3-iodopropanoate

Product 1

HCID 24727441Ethyl 4-cyclopropyl-4-oxobutanoate

Sources & evidence

ORD record
ord-fe56f10e5ecb44538942a28273bd06a1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…