Acetate → ethyl 1-[4-[4-(6-oxopyridazin-1-yl)phenyl]phenyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxylate

HRID 310750Notes

Reaction equation

HRID 310750 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][c:11](-[n:14]3[n:15][cH:16][cH:17][cH:18][c:19]3=[O:20])[cH:12][cH:13]2)[cH:6][cH:7]1.[C:63](=[O:64])([O-:65])[O-:66].[CH2:82]1[O:83][CH2:84][CH2:85][CH2:86]1.[CH3:21][C:22]1([CH3:23])[c:24]2[cH:25][cH:26][cH:27][c:28]([P:29]([c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[c:36]3[cH:37][cH:38][cH:39][cH:40][cH:41]3)[c:42]2[O:43][c:44]2[c:45]1[cH:46][cH:47][cH:48][c:49]2[P:50]([c:51]1[cH:52][cH:53][cH:54][cH:55][cH:56]1)[c:57]1[cH:58][cH:59][cH:60][cH:61][cH:62]1.[CH3:87][CH2:88][O:89][C:90]([CH3:91])=[O:92].[Cs+:67].[Cs+:68].[NH:69]1[CH:70]2[CH:71]([CH2:72][CH2:73]1)[CH2:74][N:75]([C:77](=[O:78])[O:79][CH2:80][CH3:81])[CH2:76]2.[O-:94][C:95]([CH3:96])=[O:97].[O-:98][C:99]([CH3:100])=[O:101].[Pd+2:93]>>[c:2]1([N:69]2[CH:70]3[CH:71]([CH2:72][CH2:73]2)[CH2:74][N:75]([C:77](=[O:78])[O:79][CH2:80][CH3:81])[CH2:76]3)[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][c:11](-[n:14]3[n:15][cH:16][cH:17][cH:18][c:19]3=[O:20])[cH:12][cH:13]2)[cH:6][cH:7]1

Participants

10

Reactant 9

HCID 175Acetate2×HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 19100952Ethyl hexahydropyrrolo[3,4-B]pyrrole-5(1H)-carboxylateHCID 684968382-(4'-Bromobiphenyl-4-yl)pyridazin-3(2H)-one

Product 1

HCID 178473303ethyl 1-[4-[4-(6-oxopyridazin-1-yl)phenyl]phenyl]-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxylate

Sources & evidence

ORD record
ord-b8a584825faa4f5f870bd23dd72a3010
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…