Chloride → 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-(4,4-dimethyl-2-oxo-1-piperidinyl)-6H-pyrano[2,3-f]benzo-2,1,3-oxadiazole

HRID 311500Notes

Reaction equation

HRID 311500 reaction equation
[Br:25][CH2:26][CH2:27][C:28]([CH2:29][C:30](=[O:31])[Cl:32])([CH3:33])[CH3:34].[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[CH3:1][C:2]1([CH3:17])[CH:3]([OH:16])[CH:4]([NH2:15])[c:5]2[c:6]([cH:7][c:8]3[c:9]([n:10][o:11][n:12]3)[cH:13]2)[O:14]1.[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[Cl-:35].[Na+:36]>>[CH3:1][C:2]1([CH3:17])[CH:3]([OH:16])[CH:4]([N:15]2[CH2:26][CH2:27][C:28]([CH3:33])([CH3:34])[CH2:29][C:30]2=[O:31])[c:5]2[c:6]([cH:7][c:8]3[c:9]([n:10][o:11][n:12]3)[cH:13]2)[O:14]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 923Sodium ionHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 11107308(+)-7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano[2,3-f]benz-2,1,3-oxadiazoleHCID 190434955-Bromo-3,3-dimethylpentanoyl chloride

Product 1

HCID 197348477,8-dihydro-6,6-dimethyl-7-hydroxy-8-(4,4-dimethyl-2-oxo-1-piperidinyl)-6H-pyrano[2,3-f]benzo-2,1,3-oxadiazole

Sources & evidence

ORD record
ord-4a4f72515ce4498890f345c7b15b143a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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