Ammonium → 4-(2-Fluoro-6-methoxy-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[N:22]1[CH2:23][CH2:24][C:25](=[O:28])[CH2:26][CH2:27]1.[CH2:10]([Li:11])[CH2:12][CH2:13][CH3:14].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:36][CH2:37][O:38][C:39](=[O:40])[CH3:41].[Cl-:29].[F:1][c:2]1[cH:3][c:4]([O:8][CH3:9])[cH:5][cH:6][cH:7]1.[NH4+:30]>>[F:1][c:2]1[c:3]([C:25]2([OH:28])[CH2:24][CH2:23][N:22]([C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:21])[CH2:27][CH2:26]2)[c:4]([O:8][CH3:9])[cH:5][cH:6][cH:7]1Participants
8
Sources & evidence
- ORD record
- ord-470bb007ecd44aa784f64a208a0efc89
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
Loading…