Hydrochloric Acid → 1-[4-(4-Chloro-phenoxy)-phenyl]-5-(3-trifluoromethyl-phenyl)-pyrrolidin-2-one

HRID 312935Notes

Reaction equation

HRID 312935 reaction equation
[ClH:39].[N:1]([O:2][C:3]([CH3:4])([CH3:5])[CH3:6])=[O:7].[NH2:8][c:9]1[c:10]([C:35]([F:36])([F:37])[F:38])[cH:11][c:12]([CH:15]2[CH2:16][CH2:17][C:18](=[O:34])[N:19]2[c:20]2[cH:21][cH:22][c:23]([O:26][c:27]3[cH:28][cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[cH:24][cH:25]2)[cH:13][cH:14]1.[O:40]=[CH:41][N:42]([CH3:43])[CH3:44]>>[cH:9]1[c:10]([C:35]([F:36])([F:37])[F:38])[cH:11][c:12]([CH:15]2[CH2:16][CH2:17][C:18](=[O:34])[N:19]2[c:20]2[cH:21][cH:22][c:23]([O:26][c:27]3[cH:28][cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[cH:24][cH:25]2)[cH:13][cH:14]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 10906Tert-Butyl nitriteHCID 594859225-(4-Amino-3-trifluoromethyl-phenyl)-1-[4-(4-chloro-phenoxy)-phenyl]-pyrrolidin-2-one

Product 1

HCID 594860141-[4-(4-Chloro-phenoxy)-phenyl]-5-(3-trifluoromethyl-phenyl)-pyrrolidin-2-one

Sources & evidence

ORD record
ord-9543aaf7f455411e80303cab2412f60c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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