Methane → HCID 11254099, compound

HRID 31496Notes

Reaction equation

HRID 31496 reaction equation
[N:1]1([C:6]([C:8]2([C:11]3[CH:12]=[CH:13][C:14]([Cl:20])=[C:15]([N+:17]([O-])=O)[CH:16]=3)[CH2:10][CH2:9]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(O)C.C.[H][H]>C(OCC)(=O)C.[Pd]>[N:1]1([C:6]([C:8]2([C:11]3[CH:12]=[CH:13][C:14]([Cl:20])=[C:15]([CH:16]=3)[NH2:17])[CH2:10][CH2:9]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

7

Reactant 4

HCID 297MethaneHCID 702EthanolHCID 15520870HCID 15520870, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 11254099HCID 11254099, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

1.8 g (8.14 mmol) of 5-[1-(pyrrolidin-1-yl-carbonyl)-cyclopropyl]-2-chloro-nitrobenzene are dissolved in 30 ml of ethyl acetate and 30 ml of ethanol and after the addition of 0.8 g palladium on active charcoal (10%) hydrogenated for 3 hours at ambient temperature with hydrogen. Then the catalyst is filtered off and the filtrate is evaporated down.

Workup

  1. filtrationThen the catalyst is filtered off
  2. customthe filtrate is evaporated down

Sources & evidence

ORD record
ord-9fc8f498ad224429bd573b1a57ac66fb
Source dataset
uspto-grants-2008_09
Patent number
US07425641B2

Reaction notes

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