Hydrochloric Acid → HCID 58646671, compound

HRID 31532Notes

Reaction equation

HRID 31532 reaction equation
C[O:2][C:3]([C:5]1[N:6]([CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[N:7]=[C:8]([NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH:9]=1)=[O:4].[OH-].[Li+].Cl>O1CCCC1>[C:14]([O:13][C:11]([NH:10][C:8]1[CH:9]=[C:5]([C:3]([OH:4])=[O:2])[N:6]([CH2:18][C:19]([OH:21])=[O:20])[N:7]=1)=[O:12])([CH3:17])([CH3:15])[CH3:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 58646674HCID 58646674, compound

Product 1

HCID 58646671HCID 58646671, compoundYield 122.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 5-tert-Butoxycarbonylamino-2-tert-butoxycarbonylmethyl-2H-pyrazole-3-carboxylic acid methyl ester (0.5 gm) dissolved in 25 ml of tetrahydrofuran was added 5 ml of 1M lithium hydroxide. After stirring the reaction mixture at 60 C for 2 hours, 1N hydrochloric acid was added and the product extracted with dichloromethane. The extract was dried over magnesium sulfate, filtered and evaporated to obtain 0.49 gm of title product. ESI M+1=286.

Workup

  1. extractionthe product extracted with dichloromethane
  2. dry with materialThe extract was dried over magnesium sulfate
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-c9d0a650785e48d2b2c404f41e04eaa4
Source dataset
uspto-grants-2008_09
Patent number
US07425640B2

Reaction notes

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