Dimethylformamide → 1-[5-(4-Bromophenyl)-3-methyl-1,2-oxazol-4-yl]-4-phenylbut-3-en-1-ol

HRID 315626Notes

Reaction equation

HRID 315626 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH:14]([CH2:15][CH:16]=[CH2:17])[OH:18])[c:10]([CH3:13])[n:11][o:12]2)[cH:6][cH:7]1.[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[I:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[Pd:38]([Cl:39])[Cl:40].[c:41]1([P:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[cH:55][cH:56][cH:57][cH:58][cH:59]1.[c:60]1([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1>>[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH:14]([CH2:15][CH:16]=[CH:17][c:20]3[cH:21][cH:22][cH:23][cH:24][cH:25]3)[OH:18])[c:10]([CH3:13])[n:11][o:12]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 11575IodobenzeneHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 665813481-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]but-3-en-1-ol

Product 1

HCID 670929211-[5-(4-Bromophenyl)-3-methyl-1,2-oxazol-4-yl]-4-phenylbut-3-en-1-ol

Sources & evidence

ORD record
ord-352c1aeb82dc4a3cb53ee44e03250f25
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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