1,2-Dichloroethane → N-(5-(1H-pyrazol-4-yl)thiazolo[5,4-b]pyridin-2-yl)-4-cyclopropylbenzamide

HRID 316207Notes

Reaction equation

HRID 316207 reaction equation
[CH2:38]([Cl:39])[CH2:40][Cl:41].[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[CH:16]1([c:19]2[cH:20][cH:21][c:22]([C:23](=[O:24])[OH:25])[cH:26][cH:27]2)[CH2:17][CH2:18]1.[O:49]=[CH:50][N:51]([CH3:52])[CH3:53].[OH:28][n:29]1[c:30]2[c:31]([cH:32][cH:33][cH:34][cH:35]2)[n:36][n:37]1.[nH:1]1[n:2][cH:3][c:4](-[c:6]2[cH:7][cH:8][c:9]3[c:10]([n:11]2)[s:12][c:13]([NH2:15])[n:14]3)[cH:5]1>>[nH:1]1[n:2][cH:3][c:4](-[c:6]2[cH:7][cH:8][c:9]3[c:10]([n:11]2)[s:12][c:13]([NH:15][C:23]([c:22]2[cH:21][cH:20][c:19]([CH:16]4[CH2:17][CH2:18]4)[cH:27][cH:26]2)=[O:24])[n:14]3)[cH:5]1

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 2820644-Cyclopropylbenzoic acidHCID 580153785-(1H-pyrazol-4-yl)thiazolo[5,4-b]pyridin-2-amine

Product 1

HCID 44547804N-(5-(1H-pyrazol-4-yl)thiazolo[5,4-b]pyridin-2-yl)-4-cyclopropylbenzamide

Sources & evidence

ORD record
ord-7af2b9063ead408abb0086cf78667ac9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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