反应详情

A mixture of 1-bromobutan-2-one (10 g, 66.2 mmol), potassium acetate (7.8 g, 79.4 mmol), and N,N-dimethylformamide (50 ml) was stirred at room temperature for 5 days. Water was added to the reaction mixture and extracted with diethyl ether twice. The organic layers were combined and washed with a saturated saline solution, dried over magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure to obtain the title compound (8.24 g) in the form of a mixture with N,N-dimethylformamide.

1. extractionextracted with diethyl ether twice
2. washwashed with a saturated saline solution
3. dry with materialdried over magnesium sulfate
4. filtrationfiltrated
5. concentrationThe filtrate was concentrated under reduced pressure