反应详情

温度

-20 °C

A mixture of 2,4-dichlorobenzoyl chloride (4.5 g) and copper (I) iodide (200 mg) in dry THF (30 ml) was cooled to −20° C. under argon. Then a solution of n-propyl magnesium chloride (2 M in ether, 11.0 ml) was added dropwise. Ten minutes after addition was complete, the cooling bath was removed and the mixture stirred for 1 hour. Water was carefully added, followed by extraction with toluene. The toluene layer was washed with dilute HCl, water, saturated sodium bicarbonate solution, dried and concentrated in vacuo to give 1-(2,4-dichlorophenyl)butan-1-one (4.0 g).

1. additionTen minutes after addition
2. customthe cooling bath was removed
3. additionWater was carefully added
4. extractionfollowed by extraction with toluene
5. washThe toluene layer was washed with dilute HCl, water, saturated sodium bicarbonate solution
6. customdried
7. concentrationconcentrated in vacuo