Tetrahydrofuran → 4-(3-{2-[Tert-butoxycarbonyl-(3,4-difluoro-phenyl)-amino]-acetylamino}-4-methyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([c:9]1[cH:10][c:11]([F:16])[c:12]([F:15])[cH:13][cH:14]1)[CH2:17][C:18](=[O:19])[OH:20].[C:36]([CH3:37])([CH3:38])([CH3:39])[O:40][C:41](=[O:42])[N:43]1[CH2:44][CH2:45][N:46]([CH2:49][c:50]2[cH:51][c:52]([NH2:57])[c:53]([CH3:56])[cH:54][cH:55]2)[CH2:47][CH2:48]1.[CH2:28]([O:29][C:30]([Cl:31])=[O:32])[CH:33]([CH3:34])[CH3:35].[CH3:21][CH2:22][N:23]([CH2:24][CH3:25])[CH2:26][CH3:27].[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]([c:9]1[cH:10][c:11]([F:16])[c:12]([F:15])[cH:13][cH:14]1)[CH2:17][C:18](=[O:20])[NH:57][c:52]1[cH:51][c:50]([CH2:49][N:46]2[CH2:45][CH2:44][N:43]([C:41]([O:40][C:36]([CH3:37])([CH3:38])[CH3:39])=[O:42])[CH2:48][CH2:47]2)[cH:55][cH:54][c:53]1[CH3:56]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-079f7d05a5b445a78c982021d5d6fbd5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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