Dichloromethane → N,N-di(1,1-dimethylethoxycarbonyl)-3-(1-(2,3-difluorophenyl)-1H-tetrazol-5-yl)-5-(2-(trimethylsilyl)ethynyl)pyridin-2-amine

HRID 320250Notes

Reaction equation

HRID 320250 reaction equation
[C:36](#[CH:37])[Si:38]([CH3:39])([CH3:40])[CH3:41].[CH2:42]([NH:43][CH2:44][CH3:45])[CH3:46].[CH2:47]([Cl:48])[Cl:49].[CH3:1][C:2]([CH3:3])([O:4][C:5](=[O:6])[N:7]([c:8]1[n:9][cH:10][c:11]([Br:27])[cH:12][c:13]1-[c:14]1[n:15][n:16][n:17][n:18]1-[c:19]1[c:20]([F:26])[c:21]([F:25])[cH:22][cH:23][cH:24]1)[C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH3:35].[Cu:50][I:51]>>[CH3:1][C:2]([CH3:3])([O:4][C:5](=[O:6])[N:7]([c:8]1[n:9][cH:10][c:11]([C:37]#[C:36][Si:38]([CH3:39])([CH3:40])[CH3:41])[cH:12][c:13]1-[c:14]1[n:15][n:16][n:17][n:18]1-[c:19]1[c:20]([F:26])[c:21]([F:25])[cH:22][cH:23][cH:24]1)[C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH3:35]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8021DiethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 58179849N,N-di(1,1-dimethylethoxycarbonyl)-3-(1-(2,3-difluorophenyl)-1H-tetrazol-5-yl)-5-bromopyridin-2-amine

Product 1

HCID 58179633N,N-di(1,1-dimethylethoxycarbonyl)-3-(1-(2,3-difluorophenyl)-1H-tetrazol-5-yl)-5-(2-(trimethylsilyl)ethynyl)pyridin-2-amine

Sources & evidence

ORD record
ord-1d0d593a4b454c22936de2d49655e85e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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