Dimethylformamide → 2-benzyl-6-bromo-3-hydroxymethyl-4-phenyl-2H-isoquinolin-1-one

HRID 321234Notes

Reaction equation

HRID 321234 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[n:8]1[c:9](=[O:28])[c:10]2[cH:11][cH:12][c:13]([Br:27])[cH:14][c:15]2[c:16](-[c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[c:17]1[C:18](=[O:19])[OH:20].[Cl:29][C:30]([C:31]([Cl:32])=[O:33])=[O:34].[O:35]=[CH:36][N:37]([CH3:38])[CH3:39].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[n:8]1[c:9](=[O:28])[c:10]2[cH:11][cH:12][c:13]([Br:27])[cH:14][c:15]2[c:16](-[c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[c:17]1[CH2:18][OH:19]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 230606482-benzyl-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid

Product 1

HCID 230609532-benzyl-6-bromo-3-hydroxymethyl-4-phenyl-2H-isoquinolin-1-one

Sources & evidence

ORD record
ord-148adcf577a44896a9e4cf094b1bf5cf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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