Triethylamine → HCID 9838011, compound

HRID 323772Notes

Reaction equation

HRID 323772 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C@H:10]3[CH2:12][C@H:11]3NC)[C:4]=2[CH2:3][CH2:2]1.[CH2:15]([N:17](CC)CC)C.[CH:22]1([C:25](Cl)=[O:26])[CH2:24][CH2:23]1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C@H:10]3[CH2:12][C@H:11]3[CH2:15][NH:17][C:25]([CH:22]3[CH2:24][CH2:23]3)=[O:26])[C:4]=2[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 54474819HCID 54474819, compound

Product 1

HCID 9838011HCID 9838011, compoundYield 43.3%

Procedure

The title compound was prepared by the general procedure described in Example 1 using (cis)-2-(2,3-dihydrobenzofuran-4-yl)cycloprop-1-yl methyl amine (0.79 mmol), triethylamine (2.37 mmol) and cyclopropane carbonyl chloride (0.95 mmol). Purification by silica gel column chromatography (Hex:EtOAc, 2:1) provided 88 mg of the desired product (43%) as a white wax. HPLC purity=92%.

Workup

  1. customThe title compound was prepared by the general procedure
  2. customPurification by silica gel column chromatography (Hex:EtOAc, 2:1)

Sources & evidence

ORD record
ord-d348a591e1cc4b59ae47a209ce7006b2
Source dataset
uspto-grants-2001_04
Patent number
US06214869B1

Reaction notes

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