Triethylamine → HCID 9795147, compound

HRID 323774Notes

Reaction equation

HRID 323774 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C@H:10]3[CH2:12][C@H:11]3NC)[C:4]=2[CH2:3][CH2:2]1.[CH2:15]([N:17](CC)CC)C.[C:22](Cl)(=[O:26])[CH:23]([CH3:25])[CH3:24]>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C@H:10]3[CH2:12][C@H:11]3[CH2:15][NH:17][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[C:4]=2[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 62325Isobutyryl chlorideHCID 54474819HCID 54474819, compound

Product 1

HCID 9795147HCID 9795147, compoundYield 37.1%

Procedure

The title compound was prepared by the general procedure described in Example 1 using (cis)-2-(2,3-dihydrobenzofuran-4-yl)cycloprop-1-yl methyl amine (0.79 mmol), triethylamine (2.37 mmol) and isobutyryl chloride (0.95 mmol). Purification by recrystallization from EtOAc/Hexanes provided 76 mg of the desired product (37%) as colorless plates. HPLC purity>98%. m.p. 125-126°;

Workup

  1. customThe title compound was prepared by the general procedure
  2. customPurification
  3. customby recrystallization from EtOAc/Hexanes

Sources & evidence

ORD record
ord-3aa123863fc3470496e7525d60f4347e
Source dataset
uspto-grants-2001_04
Patent number
US06214869B1

Reaction notes

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