3-Methylbenzoic acid → HCID 54031423, compound

After m-toluic acid (500 mg, produced by Wako Pure Chemical Industries) was dissolved in dichloromethane (10 ml), chloromethylmethyl ether (360 μl) and triethylamine (665 μl) were added, followed by stirring at room temperature for 2 hours. After ethyl acetate (50 ml) was added, the reaction mixture was washed with 0.01M hydrochloric acid, 2% aqueous sodium hydrogen carbonate and water, each in an amount of (2×30 ml). The organic layer obtained was dried over anhydrous sodium sulfate, after which it was concentrated under reduced pressure to yield a brown oily substance (588 mg). This oily substance (300 mg) was dissolved in carbon tetrachloride (20 ml); N-bromosuccinimide (296 mg) and 2,2′-azobisisobutyronitrile (3.0 mg) were added, followed by stirring at 90° C. for 4 hours. After filtration to remove the succinimide, the reaction mixture was concentrated. To the oily residue, hexane was added, followed by stirring; the supernatant obtained was concentrated under reduced pressure to yield 3-(bromomethyl) benzoic acid methoxymethyl ester (374 mg) as a colorless oily substance.

1. washthe reaction mixture was washed with 0.01M hydrochloric acid, 2% aqueous sodium hydrogen carbonate and water
2. customThe organic layer obtained
3. dry with materialwas dried over anhydrous sodium sulfate
4. concentrationafter which it was concentrated under reduced pressure
5. customto yield a brown oily substance (588 mg)
6. stirringby stirring at 90° C. for 4 hours
7. filtrationAfter filtration
8. customto remove the succinimide
9. concentrationthe reaction mixture was concentrated
10. additionTo the oily residue, hexane was added
11. stirringby stirring
12. customthe supernatant obtained
13. concentrationwas concentrated under reduced pressure

ORD record

ord-6b0bbcab502a44828f033a0867f42a9b

Source dataset

uspto-grants-2001_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06221637B1