Water → HCID 22001504, compound

HRID 324965Notes

Reaction equation

HRID 324965 reaction equation
F[C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][CH:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][C:3]=1[S:20](=[O:28])(=[O:27])[NH:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25].[C:29]1([OH:35])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C(=O)C>[O:35]([C:2]1[CH:19]=[CH:18][C:5]([C:6]([NH:8][CH:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][C:3]=1[S:20](=[O:28])(=[O:27])[NH:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

6

Reactant 4

HCID 962WaterHCID 996PhenolHCID 11430Potassium CarbonateHCID 22001501HCID 22001501, compound

Product 1

HCID 22001504HCID 22001504, compoundYield 69.3%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

A solution of 100 mg of 4-fluoro-N-indan-1-yl-3-(3-methyl-butylsulfamoyl)benzamide (Example 41), 26 mg of phenol, and 100 mg of potassium carbonate in 4 ml of N,N-dimethylacetamide was heated to 100° C. for 6 h. After water had been added and the precipitated product filtered off with suction, 82 mg of 4-phenoxy-N-indan-1-yl-3-(3-methyl-butylsulfamoyl)benzamide were obtained; m.p. 73° C.

Workup

  1. filtrationthe precipitated product filtered off with suction

Sources & evidence

ORD record
ord-c42add06fbfc427d8b3589569a88a26c
Source dataset
uspto-grants-2001_04
Patent number
US06221866B1

Reaction notes

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