反应详情

温度

60 °C

2M HCl (8 mL) and conc. H2SO4 (0.5 mL) were added to a solution of 6-[1-(2,2-dimethoxyethyl)-4-phenyl-1H-imidazol-5-yl]thieno[2,3-d]pyrimidin-4-amine (Example 64) (1.54 g) in THF (20 mL). The reaction was heated at 60° C. for 72 hours, allowed to cool to ambient temperature and then poured into NaHCO3 (aq. 50% sat.) (100 mL). The resultant precipitate was filtered to afford the title compound as a pale yellow solid (1 g, 74%) (used without further purification);

1. temperatureto cool to ambient temperature
2. filtrationThe resultant precipitate was filtered