反应详情

A solution of 2-[1-(4-chlorophenyl)cyclobutyl]acetonitrile (30 g) prepared as described in Example 1 in ether (100 ml) was added to the reaction product of methyl bromide gas and magnesium turnings (5.95 g) in ether (80 ml). The mixture was heated under reflux for four hours. Ice and then concentrated hydrochloric acid (105 ml) were added and the mixture heated under reflux until all solid material had dissolved. The aqueous layer was washed with ether and the ether used for washing was combined with the ether phase of the reaction mixture. The combined ether extracts were washed with water, dried and evaporated to yield a residue which was distilled twice to yield 1-[1-(4-chlorophenyl)cyclobutyl]propan-2-one (b.p. 133°-136°/2.5 mm Hg).

1. temperatureThe mixture was heated
2. temperatureunder reflux for four hours
3. temperaturethe mixture heated
4. temperatureunder reflux until all solid material
5. dissolutionhad dissolved
6. washThe aqueous layer was washed with ether
7. washfor washing
8. washThe combined ether extracts were washed with water
9. customdried
10. customevaporated
11. customto yield a residue which
12. distillationwas distilled twice