Propylamine → HCID 14995355, compound

HRID 326242Notes

Reaction equation

HRID 326242 reaction equation
[CH2:1]([NH2:4])[CH2:2][CH3:3].C(N(CC)CC)C.Br[CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]2[O:23][CH2:22][C:21](=[O:24])[NH:20][C:19]=2[CH:25]=1>CN(C)C=O>[CH2:1]([NH:4][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]2[O:23][CH2:22][C:21](=[O:24])[NH:20][C:19]=2[CH:25]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 7852PropylamineHCID 8471TriethylamineHCID 14995354HCID 14995354, compound

Product 1

HCID 14995355HCID 14995355, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a round-bottomed flask equipped with a mechanical stirrer and a calcium chloride guard tube, 0.01 mol of n-propylamine and 0.015 mol of triethylamine are added to a solution of 6-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine in 40 cm3 of dimethylformamide. The mixture is heated to reflux for 15 hours and the precipitate formed is drained in the heated state. The residue is evaporated under vacuum and the product is recrystallized.

Workup

  1. customIn a round-bottomed flask equipped with a mechanical stirrer and a calcium chloride guard tube
  2. temperatureThe mixture is heated
  3. temperatureto reflux for 15 hours
  4. customthe precipitate formed
  5. customThe residue is evaporated under vacuum
  6. customthe product is recrystallized

Sources & evidence

ORD record
ord-8be2b0d58b2b4756b51f67a340bfff7b
Source dataset
uspto-grants-1993_12
Patent number
US05268381

Reaction notes

Loading…