1-Iodopropane → 2-Chloro-5-(propane-1-sulfonyl)-benzoic acid

HRID 32669Notes

Reaction equation

HRID 32669 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl[C:16]1C=CC(S(O)=O)=C[C:17]=1C(O)=O.ICCC>C(O)CC>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH2:14][CH2:16][CH3:17])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 336431-IodopropaneHCID 23291322-Chloro-5-(methylsulphonyl)benzoic acidHCID 151129042-Chloro-5-sulfino-benzoic acid

Product 1

HCID 431410002-Chloro-5-(propane-1-sulfonyl)-benzoic acidYield 3%

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 2-Chloro-5-methanesulfonyl-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and 1-iodopropane in 20 ml propanol/20 ml water and obtained in 3% yield. MS (m/e): 261.1 (MH−, 100%).

Workup

  1. customobtained in 3% yield

Sources & evidence

ORD record
ord-ed83c1a300cb49fd8b0b7ca414a18e3f
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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