反应详情

A solution of the Grignard Reagent prepared from 1A (72 g) and Mg (7.75 g) in dry THF 250 ml) is added dropwise to a stirred, cooled (-78° C.) solution of tri-isopropyl borate (109.1 g) in dry THF 40 ml) under dry N2. The stirred mixture is allowed to warm to room temperature overnight and stirred with 10% HCl (320 ml) at room temperature for 1 hr. The product is extracted into ether twice, and the combined etheral extracts are washed with water and dried (MgSO4). Solvent is removed in vacuo to yield a colourless solid, mp =80°-85° C.

1. additionis added dropwise to a stirred
2. extractionThe product is extracted into ether twice
3. washthe combined etheral extracts are washed with water
4. dry with materialdried (MgSO4)
5. customSolvent is removed in vacuo
6. customto yield a colourless solid, mp =80°-85° C.