Guaiacol → HCID 54555031, compound

A solution of 13.0 g (0.071 mole) of 3-(2-methoxyphenoxy)-1-propanol (prepared in 68% yield from guaiacol (43.2 g, 0.35 mole), 3-bromo-1-propanol (89.3 g, 0.61 mole) and potassium carbonate (112.0 g, 0.81 mole) in 1 l of acetone and 9.0 g (0.089 mole) of triethylamine in 50 ml of methylene chloride was added dropwise (20 min.) to a stirred, cooled (ice-acetone bath) solution of 22 ml (0.0786 mole) of sulfamoyl chloride (3.57M solution in acetonitrile, Preparation 20) in 30 ml methylene chloride at such a rate the temperature was maintained at ≤12° C. The reaction mixture was stirred at ambient temperature for 3 hr. The solvents were evaporated under reduced pressure and the viscous residue was triturated with 300 ml of ethyl acetate and the solids removed by filtration. The filtrate was washed with three 300 ml portions of water, dried (magnesium sulfate) and the solvent evaporated under reduced pressure to yield 11.7 g (63%) of a colorless, viscous oil that solidified upon standing. The solid was recrystallized from methylene choride-petroleum ether (30°-60° C.) to give 6.9 g (37%) of the title compound as a white solid, mp 80°-83° C.

1. additionwas added dropwise (20 min.) to a stirred
2. temperaturewas maintained at ≤12° C
3. customThe solvents were evaporated under reduced pressure
4. customthe viscous residue was triturated with 300 ml of ethyl acetate
5. customthe solids removed by filtration
6. washThe filtrate was washed with three 300 ml portions of water
7. dry with materialdried (magnesium sulfate)
8. customthe solvent evaporated under reduced pressure
9. customto yield 11.7 g (63%) of a colorless, viscous oil that
10. customThe solid was recrystallized from methylene choride-petroleum ether (30°-60° C.)

ORD record

ord-a7dafc6350b144328fbf1810b1a96061

Source dataset

uspto-grants-1993_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05273993