反应详情

A mixture of 4.17 g. of 2-(4-phenyl-4-hydroxypiperidinomethyl)-6-nitro-1-tetralone hydrochloride, 20 g. of iron-(II) sulfate heptahydrate, 45 ml. of water and 0.15 ml. of concentrated hydrochloric acid is heated at 100° with stirring. 10 ml. of concentrated ammonium hydroxide solution are added at 80° and the mixture is heated for 10 minutes more on a steam bath. It is allowed to cool, extracted with chloroform and worked up to give 2-(4-phenyl-4-hydroxypiperidinomethyl)-6-amino-1-tetralone.

1. additionA mixture of 4.17 g
2. temperaturethe mixture is heated for 10 minutes more on a steam bath
3. temperatureto cool
4. extractionextracted with chloroform