反应详情

Methyl-2-furoate (1.58 g, 0.0125 mol) was dissolved in 100 mL of dry THF. A dropping funnel containing 50 mL of a 0.5 M solution of 2-methoxyphenylmagnesium bromide in THF (Aldrich) was attached to the reaction flask and the system was purged with argon. The reaction flask was submerged in an ice bath for 5 minutes, at which time the Grignard solution was added drop-wise over 15 minutes. After addition was complete, the reaction was allowed to warm to room temperature and was stirred overnight. A brown solution resulted. This solution was added to 150 g crushed ice and the slush was stirred with ˜0.5 g sodium bicarbonate during drop-wise addition of conc. HCl. A lavender color was observed upon addition of acid, which was continued until effervescence was observed. The resulting neutral suspension was extracted into ˜400 mL EtOAc and the organic layer was dried over MgSO4. Removal of solvent in vacuo gave a clear/yellow oil. The oil was purified by silica gel column chromatography and the product eluted using a 50:50 (vol:vol) mixture of EtOAc:hexanes. The purified product was evaporated to a solid gum yielding 3.1 grams/82% yield. The product was characterized by HPLC, 1H NMR, and FAB mass spectroscopy FAB+311 m/e.

1. customthe system was purged with argon
2. additionthe Grignard solution was added drop-wise over 15 minutes
3. additionAfter addition
4. customA brown solution resulted
5. additionThis solution was added to 150 g
6. customcrushed ice
7. additionA lavender color was observed upon addition of acid, which
8. extractionThe resulting neutral suspension was extracted into ˜400 mL EtOAc
9. dry with materialthe organic layer was dried over MgSO4
10. customRemoval of solvent in vacuo
11. customgave a clear/yellow oil
12. customThe oil was purified by silica gel column chromatography
13. washthe product eluted
14. additiona 50:50 (vol:vol) mixture of EtOAc
15. customThe purified product was evaporated to a solid gum
16. customyielding 3.1 grams/82% yield