Uridine → 18771-50-1

HRID 328550Notes

Reaction equation

HRID 328550 reaction equation
[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14](=[O:15])[NH:13][C:11]2=[O:12])[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[C@H:2]1[OH:3].[OH-].[NH4+]>[Rh].O>[OH:15][CH:14]1[CH2:16][CH2:17][N:10]([C@@H:1]2[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[C@H:2]2[OH:3])[C:11](=[O:12])[NH:13]1.[C@@H:1]1([N:10]2[CH2:17][CH2:16][CH2:14][NH:13][C:11]2=[O:12])[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[C@H:2]1[OH:3]

Participants

6

Reactant 2

HCID 6029UridineHCID 14923Ammonium Hydroxide

Product 2

HCID 2924318771-50-1HCID 22796909HCID 22796909, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 962WaterSolvent

Procedure

In the manner given in Example 2B, uridine was directly reduced with a rhodium on alumina catalyst in a solvent medium consisting of 1 part concentrated ammonium hydroxide and 99 parts water to give 4-hydroxy-1-β-D-ribofuranosyl-tetrahydro-2(1H)-pyrimidinone and 1-β-D-ribofuranosyl-tetrahydro-2(1H)-pyrimidinone.

Sources & evidence

ORD record
ord-0dcbfe606de640439ca678b1b5369842
Source dataset
uspto-grants-1977_04
Patent number
US04017606

Reaction notes

Loading…