Hydrochloric Acid → HCID 131710713, compound

HRID 328705Notes

Reaction equation

HRID 328705 reaction equation
[NH2:1][C@@H:2]1[CH2:11][C:10]2[C:5](=[C:6]([O:14][CH3:15])[CH:7]=[CH:8][C:9]=2[O:12][CH3:13])[CH2:4][C@H:3]1[OH:16].[ClH:17]>C(O)(C)C>[ClH:17].[NH2:1][C@@H:2]1[CH2:11][C:10]2[C:5](=[C:6]([O:14][CH3:15])[CH:7]=[CH:8][C:9]=2[O:12][CH3:13])[CH2:4][C@H:3]1[OH:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13146838(2R,3R)-3-Amino-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-ol

Product 1

HCID 131710713HCID 131710713, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

A solution of 3.7 g of trans-3-amino-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthalenol is isopropanol is converted to the hydrochloride salt by adding a solution of hydrogen chloride in isopropanol. The salt is precipitated by adding ether and recrystallized twice from isopropanol to give 1.3 g of the title compound, melting point 213°-216° C.

Workup

  1. customThe salt is precipitated
  2. additionby adding ether
  3. customrecrystallized twice from isopropanol

Sources & evidence

ORD record
ord-a2d95f76af974fd995879fcfe101f8b5
Source dataset
uspto-grants-1977_04
Patent number
US04018773

Reaction notes

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