反应详情

Following the procedure of Examples 1-E, 16-B and 17-B, 9.5 g. of benzyl 6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydroquinoline-1-carboxylate, 10.95 ml. of ethyl formate and sodium ethoxide prepared from 2.57 g. of sodium hydride and 3.23 ml. of ethanol in 120 ml. of benzene gave on work-up a yellow oil which on crystallization afforded 6.0 g. of crude product, m.p. 106°-110° C. The analytical same is recrystallized several times from methanol, m.p. 116°-118° C.

1. customon crystallization
2. customafforded 6.0 g
3. customThe analytical same is recrystallized several times from methanol, m.p. 116°-118° C.