Hydrochloric Acid → HCID 21438917, compound

HRID 329183Notes

Reaction equation

HRID 329183 reaction equation
[Na].[CH3:2][C:3]1[N:8]=[C:7]([CH3:9])[C:6]([C:10]([CH2:12][C:13](=O)[CH3:14])=[O:11])=[CH:5][N:4]=1.[ClH:16].S(Cl)([Cl:19])=O>C1(C)C=CC=CC=1>[ClH:19].[CH3:2][C:3]1[N:8]=[C:7]([CH3:9])[C:6]([CH:10]([OH:11])[CH2:12][CH:13]([Cl:16])[CH3:14])=[CH:5][N:4]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 5360545SodiumHCID 20352711HCID 20352711, compound

Product 1

HCID 21438917HCID 21438917, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of the sodium salt of (2,4-dimethyl-5-pyrimidylcarbonyl)-acetone in anhydrous toluene is saturated with hydrogen chloride and then reacted with thionyl chloride in a known manner. Reduction of the reaction product gives 1-(2,4-dimethyl-5-pyrimidyl)-3-chloro-butan-1-ol hydrochloride which is used without additional purification.

Sources & evidence

ORD record
ord-3010d82df18a409a9253a931bf65bb1a
Source dataset
uspto-grants-1977_04
Patent number
US04020071

Reaction notes

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