反应详情

To a 125 ml round-bottomed flask equipped with condenser and N2 inlet were added 2.39 g (7.5 mmol) of 4-(4-(2-chloroethyl)phenyl)-2-methylthiazole hydrobromide, 2.0 g (7.5 mmol) of N-(3-trifluoromethylphenyl)piperazine hydrochloride, 2.62 ml (15.0 mmol) of diisopropylethylamine, 1.59 g (15.0 mmol) of sodium carbonate, 5 mg of sodium iodide, and 50 ml of methylisobutylketone. The reaction was heated at reflux for 4.5 days, filtered hot to remove inorganic material, cooled, and the precipitate filtered and washed with ether and ethyl acetate. The solid was taken up in methylene chloride, hydrochloride gas bubbled through to precipitate the salt, and the resulting solid filtered, washed with methylene chloride, and dried to give a solid, m.p. 170°-175° C., 1.93 g (51%).

1. customTo a 125 ml round-bottomed flask equipped with condenser and N2 inlet
2. temperatureThe reaction was heated
3. temperatureat reflux for 4.5 days
4. filtrationfiltered hot
5. customto remove inorganic material
6. temperaturecooled
7. filtrationthe precipitate filtered
8. washwashed with ether and ethyl acetate
9. custombubbled through
10. customto precipitate the salt
11. filtrationthe resulting solid filtered
12. washwashed with methylene chloride
13. customdried
14. customto give a solid, m.p. 170°-175° C., 1.93 g (51%)