HRID329880

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID643918

2-Butenoic acid, 3-amino-, methyl ester, (2Z)-

C5H9NO2

HCID10290873

4-Benzofurazancarboxaldehyde

C7H4N2O2

结构：CC(=O)CC(=O)OCCN1CCN(C(c2ccccc2)c2ccccc2)CC1

HCID11740518

2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl 3-oxobutanoate

C23H28N2O3

PRODUCTS

生成物

结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1c1cccc2nonc12.Cl.Cl

HCID19871259

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A mixture of 2,1,3-benzoxadiazole-4-carbaldehyde, 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate and methyl 3-aminocrotonate was worked up in isopropyl alcohol in the same manner as Example 1 and the product obtained was further treated with methanolic hydrogen chloride solution to give 2-(4-benzhydryl-1-piperazinyl)ethyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride as light yellow crystals, m.p. 192°-198° C. Yield 45.0%.

WORKUP

后处理

customthe product obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-04b4bc05d1684e898c30c0fa33f2650e
来源数据集: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04892875
来源说明: uspto-grants-1990_01

反应 SMILES

[N:1]1[O:2][N:3]=[C:4]2[C:9]([CH:10]=O)=[CH:8][CH:7]=[CH:6][C:5]=12.[C:12]([O:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][N:24]([CH:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:23][CH2:22]1)(=[O:17])[CH2:13][C:14]([CH3:16])=O.[NH2:40]/[C:41](/[CH3:47])=[CH:42]\[C:43]([O:45][CH3:46])=[O:44].[ClH:48]>C(O)(C)C>[ClH:48].[ClH:48].[N:1]1[O:2][N:3]=[C:4]2[C:9]([CH:10]3[C:42]([C:43]([O:45][CH3:46])=[O:44])=[C:41]([CH3:47])[NH:40][C:14]([CH3:16])=[C:13]3[C:12]([O:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][N:24]([CH:27]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[CH2:23][CH2:22]3)=[O:17])=[CH:8][CH:7]=[CH:6][C:5]=12