反应详情

温度

80 °C

3.00 g (13.6 mmol) 4-iodophenol, 1.60 mL (15.0 mmol) 1-bromo-2-methylpropane and 7.50 g (54.5 mmol) K2CO3 are dissolved in 30 mL DMF and stirred at 80° C. for 4 h. Afterwards the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is washed with diluted aq. NaOH (2×) and water (2×), dried over MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.

1. extractionextracted with EtOAc
2. washThe organic layer is washed with diluted aq. NaOH (2×) and water (2×)
3. dry with materialdried over MgSO4
4. customthe solvent is removed in vacuo
5. customThe crude product is used without further purification