Hydrogen Peroxide → HCID 68181111, compound

HRID 330823Notes

Reaction equation

HRID 330823 reaction equation
[OH-].[Li+].OO.C[O:6][C:7](=[O:29])[C:8]([CH3:28])([C:10]1[CH:15]=[CH:14][C:13]([C:16]#[C:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH3:27])=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)[CH3:9].S([O-])(O)(=O)=O.[K+]>O.C1COCC1>[CH3:28][C:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]#[C:17][C:18]2[CH:19]=[CH:20][C:21]([O:24][CH2:25][CH2:26][CH3:27])=[CH:22][CH:23]=2)=[CH:12][CH:11]=1)([CH3:9])[C:7]([OH:29])=[O:6]

Participants

7

Reactant 4

HCID 784Hydrogen PeroxideHCID 3939Lithium HydroxideHCID 516920Potassium bisulfateHCID 66691389HCID 66691389, compound

Product 1

HCID 68181111HCID 68181111, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 26 mg (1.1 mmol) lithiumhydroxide and 99 μL (1.1 mmol) hydrogen peroxide in 0.7 mL water is added to 0.25 g (0.74 mmol) 2-methyl-2-[4-(4-propoxy-phenylethynyl)-phenyl]-propionic acid methyl ester (XI.4) in 7 mL THF. The reaction mixture is stirred at rt for 5 d. After that time, 0.5 N potassium hydrogensulfate solution is added. The precipitate is filtered off, washed with water and dried at 45° C. to yield the desired product.

Workup

  1. filtrationThe precipitate is filtered off
  2. washwashed with water
  3. customdried at 45° C.

Sources & evidence

ORD record
ord-b156f0c4a1e046219d98ee39c5f6e815
Source dataset
uspto-grants-2014_11
Patent number
US08877754B2

Reaction notes

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