反应详情

0.88 mL (11.4 mmol) 2-propanol and 3.00 (11.4 mmol) triphenylphosphine are added to 2.30 g (10.4 mmol) 4-iodo-1H-pyridin-2-one (XXI.1) in 130 mL DCM. Finally, 2.23 mL (11.4 mmol) DIAD are added at 0° C. After 5 min stirring, cooling is suspended and the mixture is stirred at rt for 2 h. After that time, the mixture is washed with water and brine, dried over sodium sulphate and the solvent is removed in vacuo. The crude product is purified by column chromatography (silicia gel; heptane/EtOAc 90/10).

1. temperaturecooling
2. stirringthe mixture is stirred at rt for 2 h
3. washAfter that time, the mixture is washed with water and brine
4. dry with materialdried over sodium sulphate
5. customthe solvent is removed in vacuo
6. customThe crude product is purified by column chromatography (silicia gel; heptane/EtOAc 90/10)