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HRID331212

反应详情

EQUATION

反应方程式

HRID 331212 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)C(=O)Cl
HCID65578

Ethanedioyl dichloride

C2Cl2O2

结构：O=C(O)C1(C(=O)Nc2ccc(F)cc2)CC1
HCID21081530

1-[(4-Fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid

C11H10FNO3

PRODUCTS

生成物

1
结构：O=C(Cl)C1(C(=O)Nc2ccc(F)cc2)CC1
HCID58083267

1-[[(4-Fluorophenyl)amino]carbonyl]cyclopropanecarbonyl chloride

C11H9ClFNO2

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Oxalyl chloride (1.0 kg) was added to a solution of 1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarboxylic acid (2.0 kg) in a mixture of THF (11 kg) and N,N-dimethylformamide (DMF; 0.02 kg) at a rate such that the batch temperature did not exceed 30° C. This solution was used in the next step without further processing.

WORKUP

后处理

  1. customdid not exceed 30° C