Hydrochloric Acid → HCID 66823383, compound

HRID 331695Notes

Reaction equation

HRID 331695 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH:12]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][N:29]([CH3:36])[S:30]([CH2:33][CH2:34][CH3:35])(=[O:32])=[O:31])[CH:23]=3)[CH2:13][NH:14]C(=O)OC(C)(C)C)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl>C(O)(C)C>[ClH:1].[NH2:14][CH2:13][CH:12]([C:22]1[CH:23]=[C:24]([CH:25]=[CH:26][CH:27]=1)[CH2:28][N:29]([CH3:36])[S:30]([CH2:33][CH2:34][CH3:35])(=[O:32])=[O:31])[C:8]1([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[CH2:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68077951HCID 68077951, compound

Product 1

HCID 66823383HCID 66823383, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

tert-Butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-(3-{[methyl(propylsulfonyl)amino]methyl}phenyl)ethyl}carbamate (20.9 mg, 0.039 mmol) was treated with hydrochloric acid in isopropanol (5 M, 1 ml) at room temperature. The solvent was evaporated in vacuo. Water (1 ml) was added and the product was freeze-dried. Yield: 16 mg (0.034 mmol, 87%)

Workup

  1. customThe solvent was evaporated in vacuo
  2. additionWater (1 ml) was added
  3. customthe product was freeze-dried

Sources & evidence

ORD record
ord-2833fdaa803d4db1aeece56a6936fcb1
Source dataset
uspto-grants-2014_11
Patent number
US08877794B2

Reaction notes

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