反应详情

温度

150 °C

Chloropyrazine S1.6 (25 mg, 0.12 mmol) was diluted with NMP (5 mL) and treated with 1-(4-(4-aminophenyl)piperazin-1-yl)ethanone (52 mg, 0.24 mmol) and DIPEA (42 uL, 0.24 mmol) and the resulting solution stirred at 150° C. for three days. The reaction mixture was diluted with water and acidified with a small amount of TFA, then purified by preparative HPLC affording the desired product (10 mg) after lyophilization. MS found for C20H25N7O2 as (M+H)+396.0. UV: λ=203, 262, 309 nm.

1. custompurified by preparative HPLC