反应详情

温度

180 °C

6-Chloro-2-methylsulfanyl-pyrimidin-4-amine (176 mg, 1 mmol) was dissolved together with tert-butyl N-(2-aminoethyl)carbamate (200 mg, 1.25 mmol) and triethylamine (174 μl, 1.25 mmol) in THF (2 ml). The mixture was stirred at 180° C. under microwave heating for 8 hours. The mixture was diluted with ethyl acetate and the resulting solution was washed with a solution of sodium bicarbonate (5%) and brine, dried over magnesium sulfate, the volatiles were removed under reduced pressure. The residue dissolved in DCM and purified by filtration over silica to yield 105 mg (0.35 mmol, 35%) MS (ESI) m/z=300.2 [M+1]+.

1. temperatureheating for 8 hours
2. washthe resulting solution was washed with a solution of sodium bicarbonate (5%) and brine
3. dry with materialdried over magnesium sulfate
4. customthe volatiles were removed under reduced pressure
5. dissolutionThe residue dissolved in DCM
6. filtrationpurified by filtration over silica
7. customto yield 105 mg (0.35 mmol, 35%)