反应详情

To a solution containing 100 mg (0.245 mmol) of 1-{1-[(S)-2-amino-3-(4-methoxy-phenyl)propionyl]-4-phenylpiperidin-4-yl}butan-1-one in 10 mL of dichloromethane are added 64 μL of diisopropylethylamine and then 74 mg (0.368 mmol) of 4-nitrophenyl chloroformate. The medium is stirred at room temperature for 1 hour 30 minutes. A solution containing 90 mg (0.489 mmol) of histamine dihydrochloride and 0.15 mL of diisopropylethylamine in 5 mL of dichloromethane and 2 mL of dimethylformamide is added to this mixture.

1. additionis added to this mixture