Hydrochloric Acid → HCID 66987930, compound

HRID 333439Notes

Reaction equation

HRID 333439 reaction equation
[CH:1]1([C:7]2([C:20](=[O:23])[CH2:21][CH3:22])[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:24]>C(OCC)(=O)C>[ClH:24].[CH:1]1([C:7]2([C:20](=[O:23])[CH2:21][CH3:22])[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66988160HCID 66988160, compound

Product 1

HCID 66987930HCID 66987930, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

549 mg (1.7 mmol) of tert-butyl 4-cyclohexyl-4-propionylpiperidine-1-carboxylate are dissolved in 2 mL (17 mmol) of 4N hydrogen chloride in ethyl acetate. The reaction mixture is stirred for 6 hours at room temperature. The solvents are evaporated off. The residue is taken up in ether and filtered off. 395 mg of 4-cyclohexyl-4-propionylpiperidine hydrochloride in the form of a white powder are obtained in a yield of 90%.

Workup

  1. customThe solvents are evaporated off
  2. filtrationfiltered off

Sources & evidence

ORD record
ord-1df68fbbfe4c4ad4b1132cd84976cb31
Source dataset
uspto-grants-2014_11
Patent number
US08877968B2

Reaction notes

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