反应详情

1-Phenylpiperazine (266 mg, 1.64 mmol) was dissolved in methanol (7 mL) in a reaction vessel and, after adding biphenyl-2-carbaldehyde (150 mg, 0.82 mmol), the mixture was stirred at room temperature for 2 hours. 2 hours later, NaBH(OAc)3 (529 mg, 2.46 mmol) was added and the mixture was further stirred for 8 hours. After the reaction was completed, the reaction solution was diluted with dichloromethane and saturated NaHCO3 solution was added. After extraction, organic layer was dried with anhydrous MgSO4 and then filtered. The filtrate was concentrated and the concentrate was purified by column chromatography (hexane:diethyl ether=8:1) to obtain 50 mg of the target compound (0.15 mmol, 18.3%).

1. stirringthe mixture was further stirred for 8 hours
2. additionwas added
3. extractionAfter extraction, organic layer
4. dry with materialwas dried with anhydrous MgSO4
5. filtrationfiltered
6. concentrationThe filtrate was concentrated
7. customthe concentrate was purified by column chromatography (hexane:diethyl ether=8:1)