反应详情

温度

40 °C

Example 1 (0.05 g) was dissolved in DMF (1 ml) and treated with chloroethylmorpholine hydrochloride (0.062 g) and potassium carbonate (0.093 g), and stirred at 40° C. for 2 h. The mixture was then heated at 80° C. for 8 h, cooled and treated with ethyl acetate and water. The organic extract was dried (over magnesium sulphate) and concentrated under reduced pressure. The residue was purified using mass directed preparative h.p.l.c. to give the title compound (0.018 g) as a white solid.

1. temperatureThe mixture was then heated at 80° C. for 8 h
2. temperaturecooled
3. extractionThe organic extract
4. dry with materialwas dried (over magnesium sulphate)
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified