反应详情

A mixture comprising 7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide (Ex 1.1, step 1) (100 mg, 0.177 mmol) and cesium carbonate (230 mg, 0.707 mmol) in DME (2.5 ml) and water (1 ml) under nitrogen was treated with 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole followed by PdCl2(dppf).CH2Cl2 adduct (7.22 mg, 8.84 μmol) and heated using microwave radiation at 100° C. for 1 hr. After cooling to RT, the reaction mixture was partitioned between water (4 ml) and EtOAc (10 ml)/MeOH (1 ml). The organic portion was separated, dried (MgSO4) and concentrated in vacuo. Purification by chromatography on silica eluting with 0-20% MeOH in DCM followed by trituration of the resulting solid with EtOAc afforded the title compound;

1. customat 100° C.
2. customfor 1 hr
3. customthe reaction mixture was partitioned between water (4 ml) and EtOAc (10 ml)/MeOH (1 ml)
4. customThe organic portion was separated
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo
7. customPurification by chromatography on silica eluting with 0-20% MeOH in DCM